The Incit teams

Team 2

Clinical and translational research in proliferative and inflammatory skin diseases.

Objectives of the research programs

Our projects aim to improve the management of patients with skin cancers and severe skin dysbiosis, ranging from epidemiology to the development of innovative therapeutic strategies, including artificial intelligence.

Research projects

Our work is organised around 5 programmes, grouped into two main research areas:

Melanoma and Immunotherapy

Clinical research, focused on the development of immunotherapies in cutaneous cancers, the implementation of clinical trials in inflammatory pathologies involving the cutaneous microbiome, such as acne; the optimisation of production processes for therapeutic TILs, and the monitoring of a national database on clinical data from melanoma patients (RicMel). Coordinated by A. Khammari and B. Dreno

Identification of molecular/immunological signatures associated with clinical responses and severe adverse events in patients treated for melanoma, and the development and validation of artificial intelligence algorithms that allow the characterisation of peri-cicatrical helioderma, as a surrogate marker for TMB, to predict patient response to immunotherapy, by exploring the immune and molecular mechanisms behind this correlation Coordinated by L. Boussemart and M. Denis

Melanoma epidemiology and prevention, with the development of new analysis methods and the optimisation of prevention strategies. Coordinated by C. Rat and G. Quereux

Skin inflammation

Characterisation of the diversity and interactions of skin commensal bacteria such as acnes and S. epidermidis on the control of cutaneous innate immunity using acne as a model. Coordinated by S. Corvec and B. Dreno

The development of a regenerativeskin dressing based on a secretome of immortalised foetal keratinocytes and fibroblasts. Coordinated by B. Dreno and A. Khammari

Graphic summary

Abstract Graph E2


Dreno et al. Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients.

Cancer Immunol Immunother 2021


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Themes addressed

Clinical research in skin diseases
Coordinated by A. Khammari and B. Dreno

Artificial intelligence and melanoma
Coordinated by L. Boussemart and M. Denis

Epidemiology and prevention of melanoma
Coordinated by C. Rat and G. Quereux

Control of cutaneous innate immunity by skin commensal bacteria
Coordinated by S. Corvec and B. Dreno

Regenerative Skin Dressing
Coordinated by B. Dreno and A. Khammari

The Research Team

Team leaders


Contact us:

Profile photo Lise Boussemart
profile photo Birgitte DRENO

5 University professors / Hospital practitioners

5 Engineers

  • K. Ducoin, IR
  • F. Marouf, IE
  • C. Berthebaud, IE
  • J. Saenz, IR
  • T. Roret, IR

Post doc

  • ________

2 project managers

2 PhD students

  • Morgane Angibaud
  • Louise Ruffier d'Epenoux

1 Lecturer / Hospital practitioner

  • G. Herbreteau, MCUPH

The Clinical Team

e6 Clinical Research Associates

  • J. Cassecuel
  • C. Dabrowski
  • Mr Denyset
  • V. Rousselet
  • Mr. Thabot
  • Roxane Mathieu


  • S. Charpentier, IE
  • A. Daminette-Normand, TCH
  • C. Leroy, TCH
  • A. Mordelet, TCH
  • A. Vallee, IE
  • L. Minier, TCH

2 Clinical research nurses

  • A. Boisrobert
  • C. Montfort

Full organisation chart of the unit

Find below the global staffing of the unit in pdf format

Scientific publications

Find the major publications of the team for the last 2 years.

Cutibacterium acnes and Staphylococcus epidermidis: the unmissable modulators of skin inflammatory response.

Dagnelie MA, Corvec S, Timon-David E, Khammari A, Dréno B.

Exp Dermatol. 2022 Mar;31(3):406-412. doi: 10.1111/exd.14467.

Positive Association Between Location of Melanoma, Ultraviolet Signature, Tumor Mutational Burden, and Response to Anti-PD-1 Therapy.

Dousset L, Poizeau F, Robert C, Mansard S, Mortier L, Caumont C, Routier É, Dupuy A, Rouanet J, Battistella M, Greliak A, Cappellen D, Galibert MD, Allayous C, Lespagnol A, Gerard É, Kerneuzet I, Roy S, Dutriaux C, Merlio JP, Vergier B, Schrock AB, Lee J, Ali SM, Kammerer-Jacquet SF, Lebbé C, Beylot-Barry M, Boussemart L.

JCO Precis Oncol. 2021 Dec 16;5:PO.21.00084. doi: 10.1200/PO.21.00084. eCollection 2021.

Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients.

Dréno B, Khammari A, Fortun A, Vignard V, Saiagh S, Beauvais T, Jouand N, Bercegay S, Simon S, Lang F, Labarrière N.

Cancer Immunol Immunother. 2021 Oct;70(10):3015-3030. doi: 10.1007/s00262-021-02961-0.

Transcriptomics Analysis Indicates Trifarotene Reverses Acne-Related Gene Expression Changes.

Dreno B, Chavda R, Julia V, Khammari A, Blanchet-Réthoré S, Krishnaswamy JK.

Front Med (Lausanne). 2021 Oct 22;8:745822. doi: 10.3389/fmed.2021.745822. eCollection 2021.

Effectiveness and safety of nivolumab in patients with advanced melanoma: A
multicenter, observational study.

Monestier S, Dalle S, Mortier L, Dutriaux C, Dalac-Rat S, Meyer N, Leccia MT, Mansard S, Montaudié H, Saiag P, Combemale P, Guillot B, Skowron F, Duval Modeste AB, Bénéton N, Hainaut E, Robert C, Arnault JP, Le Corre Y, Jouary T, Ameur N, Varey E, Khammari A, Dréno B; RIC-Mel network.

Int J Cancer. 2021 Jun 1;148(11):2789-2798. doi: 10.1002/ijc.33467. Epub 2021 Feb 19.




link linkedn team leader incit




IRS2, Nantes University

22 Boulevard Benoni Goulin

44000 Nantes

About us

Created in 2022, the INCIT(Immunology and New Concepts in Immunotherapy) research unit, directed by Frédéric Altare, is based on the desire to focus thescientific expertise of the immunology and immunotherapy teams on different pathological contexts: inflammation, cancer and infectious diseases.


Publications since 2016

Doctoral students and post-docs

Locations - Nantes and Angers